The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.
نویسندگان
چکیده
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
منابع مشابه
Prioritization of Environmental Sensitive Spots in Studies of Environmental Impact Assessment to Select the Preferred Option, Based on AHP and GIS Compound in the Gas Pipeline Project
Environmental assessments are essential in order to align the process of country's progress towards sustainable development. It is important for the project to be implemented in direction of sustainable development, which is to carry out a project in such a way that in both short and long term, the greatest advantages and the least harm are inflicted on the environment, economy, communities, an...
متن کاملPrioritization of Environmental Sensitive Spots in Studies of Environmental Impact Assessment to Select the Preferred Option, Based on AHP and GIS Compound in the Gas Pipeline Project
Environmental assessments are essential in order to align the process of country's progress towards sustainable development. It is important for the project to be implemented in direction of sustainable development, which is to carry out a project in such a way that in both short and long term, the greatest advantages and the least harm are inflicted on the environment, economy, communities, an...
متن کاملAssessment of the effects of Megaprojects Implementation on the Quality of the Surrounding Environment (case study: Velayat Park in Tehran)
Development of science and technology and the growing trend of globalization has pushed the urban communities toward competition on absorbing foreign capitals and construction of macro-scale projects. This competition has affected not only developed countries but also developing countries such as Iran- since it is expected that each urban development will finally result in an increase in the qu...
متن کاملEffects of Hadi Project Implementation on the Resilience of Rural Settlements in Oraman, Sarvabad
INTRODUCTION: Resilience is recognized as the potential capacity of a system or community to adapt or resist change in order to maintain an appropriate level of performance and structure. Moreover, governments adopt a variety of strategies to mitigate the effects of natural disasters. In this regard, the rural Hadi project is an efficient method for rural physical management. The present study...
متن کاملFishing lantern trawl; Environmental, social and economic aspects of the Oman Sea
Lanternfish is one of the most important and aquatic reserves in the Oman Sea. After the cessation of the fish lantern fishing project provided by foreign vessels owned by Iranian companies by the Iranian Fisheries Organization, the impact of the activity of foreign vessels on aquatic resources should be considered for reasons other than those envisaged in the contracts and research plans. Ligh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Twin research and human genetics : the official journal of the International Society for Twin Studies
دوره 18 4 شماره
صفحات -
تاریخ انتشار 2015